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On this site, you will learn about genital herpes and Valaciclovir, you'll realize that you can still enjoy an active life and take charge. Some of the most common adverse reactions to the drug are headache, nausea, diarrhea, and vomiting. Some of the most common adverse reactions to the drug are headache, nausea, diarrhea, and vomiting. Valtrex is also believed to reduce the risk of spreading genital herpes.