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Valtrex is most effective if it is started within 48 hours of when the rash first appears. It is started within 48 hours of when the rash first appears. Valtrex has shown promise as a treatment for infectious mononucleosis and is preventatively administered in suspected cases of herpes virus exposure. Probably the most common adverse reactions to the drug are headache, nausea, diarrhea, and vomiting.
